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BioLiP

Structure of PDB 7skm Chain C Binding Site BS01

Receptor Information
>7skm Chain C (length=300) Species: 1280 (Staphylococcus aureus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AAATGTGKGVLGDTKDININSIDGGFSLEDLTHQGKLSAYNFNDQTGQAT
LITNEDENFVKDDQRAGVDANYYAKQTYDYYKNTFGRESYDNHGSPIVSL
THVNHYGGQDNRNNAAWIGDKMIYGDGDGRTFTNLSGANDVVAHELTHGV
TQETANLEYKDQSGALNESFSDVFGYFVDDEDFLMGEDVYTPGKEGDALR
SMSNPEQFGQPSHMKDYVYTEKDNGGVHTNSGIPNKAAYNVIQAIGKSKS
EQIYYRALTEYLTSNSNFKDCKDALYQAAKDLYDEQTAEQVYEAWNEVGV
Ligand information
>7skm Chain F (length=29) Species: 7137 (Galleria mellonella) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
IRCNDKCYCEDGYARDVNGKCIPIKDCPK
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7skm Structural evidence for standard-mechanism inhibition in metallopeptidases from a complex poised to resynthesize a peptide bond.
Resolution1.85 Å
Binding residue
(original residue number in PDB)		Q317 N321 N322 V349 H352 E353 R408 H436
Binding residue
(residue number reindexed from 1)		Q109 N113 N114 V141 H144 E145 R200 H228
Enzymatic activity
Enzyme Commision number 3.4.24.29: aureolysin.
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7skm, PDBe:7skm, PDBj:7skm
PDBsum7skm
PubMed
UniProtP81177|AURE_STAAU Zinc metalloproteinase aureolysin (Gene Name=aur)

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