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BioLiP

Structure of PDB 7q42 Chain C Binding Site BS01

Receptor Information
>7q42 Chain C (length=368) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVT
VEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRH
ATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGS
SHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVAC
GSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVC
QIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKK
IVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEG
QKITRVACGSSHSVAWTT
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7q42 Crystal structure of RCC1-Like domain 2 of ubiquitin ligase HERC2 in complex with DXDKDED motif of chromatin reader BAZ2B
Resolution1.95002 Å
Binding residue
(original residue number in PDB)		L2966 D2968 S2978 K2979 K3002 R3161 A3214 Y3234 D3283 D3285 H3286 S3318 S3319
Binding residue
(residue number reindexed from 1)		L8 D10 S20 K21 K44 R203 A256 Y276 D325 D327 H328 S360 S361
Enzymatic activity
Enzyme Commision number 2.3.2.26: HECT-type E3 ubiquitin transferase.
External links
PDB RCSB:7q42, PDBe:7q42, PDBj:7q42
PDBsum7q42
PubMed
UniProtO95714|HERC2_HUMAN E3 ubiquitin-protein ligase HERC2 (Gene Name=HERC2)

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