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BioLiP

Structure of PDB 5w0m Chain C Binding Site BS01

Receptor Information
>5w0m Chain C (length=371) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EPLPPLTPKFLNILDQVCIQCYKDFSPTIIEDQAREHIRQNLESFIRQDF
PGTKLSLFGSSKNGFGFKQSDLAVCMTINGLETAEGLDCVRTIEELARVL
RKHSGLRNILPITTAKVPIVKFFHLRSGLEVDISLYNTLALHNTRLLSAY
SAIDPRVKYLCYTMKVFTKMCDIGDASRGSLSSYAYTLMVLYFLQQRNPP
VIPVLQEIYKGEKKPEIFVDGWNIYFFDQIDELPTYWSECGKNTESVGQL
WLGLLRFYTEEFDFKEHVISIRRKSLLTTFKKQWTSKYIVIEDPFDLNHN
LGAGLSRKMTNFIMKAFINGRRVFGIPPKDYPSKMEYFFDPDVLTEGELA
PNDRCCRICGKIGHFMKDCPM
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5w0m Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis.
Resolution2.298 Å
Binding residue
(original residue number in PDB)		F1045 G1046 T1101 A1102 V1104 N1124 N1130 A1163 S1164 Y1171 L1288 A1290 I1353 G1354 H1355
Binding residue
(residue number reindexed from 1)		F58 G59 T114 A115 V117 N137 N143 A176 S177 Y184 L301 A303 I362 G363 H364
Enzymatic activity
Enzyme Commision number 2.7.7.52: RNA uridylyltransferase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:5w0m, PDBe:5w0m, PDBj:5w0m
PDBsum5w0m
PubMed28671666
UniProtQ5VYS8|TUT7_HUMAN Terminal uridylyltransferase 7 (Gene Name=TUT7)

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