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Structure of PDB 5dis Chain C Binding Site BS01

Receptor Information >5dis Chain C (length=264) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] GSMEELSQALASSFSVSQDLNSTAAPHPRLKSKYSSLEQSERRRRLLELQ KSKRLDYVNHARRLAEDDWTGMKLPKHYANQLMLSEWLIDVPSDLGQEWI VVVCPVGKRALIVASRGSTSAYTKSGYCVNRFSSLLPGGNRRAKDYTILD CIYNEVNQTYYVLDVMCWRGHPFYDCQTDFRFYWMHSKLPEEEGLGEKTK LNPFKFVGLKNFPCTPESLCDVLSMDFPFEVDGLLFYHKQTHYSPGSTPL VGWLRPYMVSDVLG

Ligand information Ligand ID PRO InChI InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 InChIKey ONIBWKKTOPOVIA-BYPYZUCNSA-N SMILES Software SMILES OpenEye OEToolkits 1.5.0 C1C[C@H](NC1)C(=O)O CACTVS 3.341 OC(=O)[C@@H]1CCCN1 CACTVS 3.341 OC(=O)[CH]1CCCN1 OpenEye OEToolkits 1.5.0 C1CC(NC1)C(=O)O ACDLabs 10.04 O=C(O)C1NCCC1 Formula C5 H9 N O2 Name PROLINE ChEMBL CHEMBL54922 DrugBank DB00172 ZINC ZINC000000895360 PDB chain 5dis Chain C Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 5dis Structural and Functional Characterization of CRM1-Nup214 Interactions Reveals Multiple FG-Binding Sites Involved in Nuclear Export. Resolution 2.85 Å Binding residue (original residue number in PDB) R129 K144 W276 Binding residue (residue number reindexed from 1) R109 K124 W253 Annotation score 4

Enzymatic activity Enzyme Commision number ?

Gene Ontology Molecular Function GO:0061608 nuclear import signal receptor activity

	Biological Process
GO:0006606	protein import into nucleus
GO:0061015	snRNA import into nucleus

	Cellular Component
GO:0005634	nucleus
GO:0005737	cytoplasm

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