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Structure of PDB 4fba Chain C Binding Site BS01

Receptor Information >4fba Chain C (length=278) Species: 4513 (Hordeum vulgare) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] KMAKNVDKPLFTATFNVQASSADYATFIAGIRNKLRNPAHFSHNRPVLPP VEPNVPPSRWFHVVLKASPTSAGLTLAIRADNIYLEGFKSSDGTWWELTP GLIPGATYVGFGGTYRDLLGDTDKLTNVALGRQQLADAVTALHGRTKADK PSGPKQQQAREAVTTLLLMVNEATRFQTVSGFVAGLLHPKAVAAASGKIG NEMKAQVNGWQDLSAALLKTDVKPPPGKSPAKFAPIEKMGVRTAVQAANT LGILLFVEVPGGLTVAKALELFHASGGK

Ligand information Ligand ID ADE InChI InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) InChIKey GFFGJBXGBJISGV-UHFFFAOYSA-N SMILES Software SMILES CACTVS 3.341 Nc1ncnc2[nH]cnc12 OpenEye OEToolkits 1.5.0 c1[nH]c2c(n1)c(ncn2)N ACDLabs 10.04 n1c(c2ncnc2nc1)N Formula C5 H5 N5 Name ADENINE ChEMBL CHEMBL226345 DrugBank DB00173 ZINC ZINC000000000882 PDB chain 4fba Chain C Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 4fba Structures of the ribosome-inactivating protein from barley seeds reveal a unique activation mechanism. Resolution 1.85 Å Binding residue (original residue number in PDB) Y87 L88 G116 Y118 L170 R178 Binding residue (residue number reindexed from 1) Y84 L85 G113 Y115 L167 R175 Annotation score 4

Enzymatic activity Enzyme Commision number 3.2.2.22: rRNA N-glycosylase.

Gene Ontology Molecular Function GO:0016787 hydrolase activity GO:0030598 rRNA N-glycosylase activity GO:0090729 toxin activity

	Biological Process
GO:0017148	negative regulation of translation
GO:0031640	killing of cells of another organism
GO:0035821	modulation of process of another organism
GO:0050832	defense response to fungus

	Cellular Component
GO:0005737	cytoplasm

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