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BioLiP

Structure of PDB 3clz Chain C Binding Site BS01

Receptor Information
>3clz Chain C (length=204) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NHYGPIPGIPVGTMWRFRVQVSESGVHRPHVAGIHGRSNDGAYSLVLAGG
YEDDVDHGNFFTYTGSGGRDLSGNKRTAEQSCDQKLTNTNRALALNCFAP
INDQEGAEAKDWRSGKPVRVVRNVKGGKNSKYAPAEGNRYDGIYKVVKYW
PEKGKSGFLVWRYLLRRDDDEPGPWTKEGKDRIKKLGLTMQYPEGYLEAL
ANAH
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3clz Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		F432 R433 V446 A447 G448 A463 G465 Y466 D469 Y478 T479 S481 R491 K540
Binding residue
(residue number reindexed from 1)		F17 R18 V31 A32 G33 A48 G50 Y51 D54 Y63 T64 S66 R76 K125
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
External links
PDB RCSB:3clz, PDBe:3clz, PDBj:3clz
PDBsum3clz
PubMed18772889
UniProtQ96T88|UHRF1_HUMAN E3 ubiquitin-protein ligase UHRF1 (Gene Name=UHRF1)

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