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Structure of PDB 2xo5 Chain C Binding Site BS01

Receptor Information >2xo5 Chain C (length=734) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] NLLVTKRDGSTERINLDKIHRVLDWAAEGLHNVSISQVELRSHIQFYDGI KTSDIHETIIKAAADLISRDAPDYQYLAARLAIFHLRKKAYGQFEPPALY DHVVKMVEMGKYDNHLLEDYTEEEFKQMDTFIDHDRDMTFSYAAVKQLEG KYLVQNRVTGEIYESAQFLYILVAACLFSNYPRETRLQYVKRFYDAVSTF KISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATSSAIVKYVSQRAG IGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAAT LFYPMWHLEVESLLVLKNNRGVEGNRVRHMDYGVQINKLMYTRLLKGEDI TLFSPSDVPGLYDAFFADQEEFERLYTKYEKDDSIRKQRVKAVELFSLMM QERASTGRIYIQNVDHCNTHSPFDPAIAPVRQSNLCLEIALPTKPLNDVN DENGEIALCTLSAFNLGAINNLDELEELAILAVRALDALLDYQDYPIPAA KRGAMGRRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLK ASNELAKEQGACPWFNETTYAKGILPIDTYKKDLDTIANEPLHYDWEALR ESIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGYVSIKASKDGILR QVVPDYEHLHDAYELLWEMPGNDGYLQLVGIMQKFIDQSISANTNYDPSR FPSGKVPMQQLLKDLLTAYKFGVKTLYYQNTRDG

Ligand information >2xo5 Chain F (length=16) Species: 562 (Escherichia coli) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure] QIDSEVDTDDLSNFQL

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 2xo5 Kinetics of Radical Intermediate Formation and Deoxynucleotide Production in 3-Aminotyrosine- Substituted Escherichia Coli Ribonucleotide Reductases. Resolution 2.7 Å Binding residue (original residue number in PDB) L348 Q404 K584 K708 V709 M711 Q712 L719 K723 Binding residue (residue number reindexed from 1) L345 Q401 K581 K705 V706 M708 Q709 L716 K720

Enzymatic activity Catalytic site (original residue number in PDB) C225 N437 C439 E441 C462 Y730 Y731 Catalytic site (residue number reindexed from 1) C222 N434 C436 E438 C459 Y727 Y728 Enzyme Commision number 1.17.4.1: ribonucleoside-diphosphate reductase.

Gene Ontology Molecular Function GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor GO:0005515 protein binding GO:0005524 ATP binding GO:0016491 oxidoreductase activity GO:0042802 identical protein binding GO:0044183 protein folding chaperone

	Biological Process
GO:0006457	protein folding
GO:0009185	ribonucleoside diphosphate metabolic process
GO:0009263	deoxyribonucleotide biosynthetic process
GO:0009265	2'-deoxyribonucleotide biosynthetic process
GO:0015949	nucleobase-containing small molecule interconversion

	Cellular Component
GO:0005829	cytosol
GO:0005971	ribonucleoside-diphosphate reductase complex

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