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Structure of PDB 1rjd Chain C Binding Site BS01

Receptor Information >1rjd Chain C (length=333) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] ERIIQQTDYDALSCKLAAISVGYLPSSGLQRLSVDLSKKYTEWHRSYLIT LKKFSRRAFGKVDKAMRSSFPVMNYGTYLRTVGIDAAILEFLVANEKVQV VNLGCGSDLRMLPLLQMFPHLAYVDIDYNESVELKNSILRESEILRISLG LSKEDTAKSPFLIDQGRYKLAACDLNDITETTRLLDVCTKREIPTIVISE CLLCYMHNNESQLLINTIMSKFSHGLWISYDPIGGSQPNDRFGAIMQSNL KESRNLEMPTLMTYNSKEKYASRWSAAPNVIVNDMWEIFNAQIPESERKR LRSLQFLDELEELKVMQTHYILMKAQWHHHHHH

Ligand information Ligand ID SAM InChI InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/t7-,8+,10+,11+,14+,27-/m0/s1 InChIKey MEFKEPWMEQBLKI-FCKMPRQPSA-N SMILES Software SMILES CACTVS 3.341 C[S@@+](CC[C@H](N)C([O-])=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23 OpenEye OEToolkits 1.5.0 C[S+](CCC(C(=O)[O-])N)CC1C(C(C(O1)n2cnc3c2ncnc3N)O)O CACTVS 3.341 C[S+](CC[CH](N)C([O-])=O)C[CH]1O[CH]([CH](O)[CH]1O)n2cnc3c(N)ncnc23 OpenEye OEToolkits 1.5.0 C[S@@+](CC[C@@H](C(=O)[O-])N)C[C@@H]1[C@H]([C@H]([C@@H](O1)n2cnc3c2ncnc3N)O)O ACDLabs 10.04 [O-]C(=O)C(N)CC[S+](C)CC3OC(n2cnc1c(ncnc12)N)C(O)C3O Formula C15 H22 N6 O5 S Name S-ADENOSYLMETHIONINE ChEMBL CHEMBL1235831 DrugBank ZINC PDB chain 1rjd Chain C Residue 803 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 1rjd Structure of protein phosphatase methyltransferase 1 (PPM1), a leucine carboxyl methyltransferase involved in the regulation of protein phosphatase 2A activity Resolution 1.8 Å Binding residue (original residue number in PDB) T8 D9 R81 G105 C106 D128 Y129 D175 L176 N177 E201 C202 L203 Binding residue (residue number reindexed from 1) T7 D8 R80 G104 C105 D127 Y128 D174 L175 N176 E200 C201 L202 Annotation score 5

Enzymatic activity Enzyme Commision number 2.1.1.233: [phosphatase 2A protein]-leucine-carboxy methyltransferase.

Gene Ontology Molecular Function GO:0008168 methyltransferase activity GO:0018423 protein C-terminal leucine carboxyl O-methyltransferase activity

	Biological Process
GO:0010506	regulation of autophagy
GO:0032259	methylation
GO:0065003	protein-containing complex assembly

	Cellular Component
GO:0005575	cellular_component

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