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Structure of PDB 1pmm Chain C Binding Site BS01

Receptor Information >1pmm Chain C (length=449) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] KQVTDLRSELLDSRFGAKSISTIAESKRFPLHEMRDDVAFQIINDELYLD GNARQNLATFCQTWDDENVHKLMDLSINKNWIDKEEYPQSAAIDLRCVNM VADLWHAPAPKNGQAVGTNTIGSSEACMLGGMAMKWRWRKRMEAAGKPTD KPNLVCGPVQICWHKFARYWDVELREIPMRPGQLFMDPKRMIEACDENTI GVVPTFGVTYTGNYEFPQPLHDALDKFQADTGIDIDMHIDAASGGFLAPF VAPDIVWDFRLPRVKSISASGHKFGLAPLGCGWVIWRDEEALPQELVFNV DYLGGQIGTFAINFSRPAGQVIAQYYEFLRLGREGYTKVQNASYQVAAYL ADEIAKLGPYEFICTGRPDEGIPAVCFKLKDGEDPGYTLYDLSERLRLRG WQVPAFTLGGEATDIVVMRIMCRRGFEMDFAELLLEDYKASLKYLSDHP

Ligand information Ligand ID PLP InChI InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14) InChIKey NGVDGCNFYWLIFO-UHFFFAOYSA-N SMILES Software SMILES CACTVS 3.341 Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O OpenEye OEToolkits 1.5.0 Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O ACDLabs 10.04 O=P(O)(O)OCc1cnc(c(O)c1C=O)C Formula C8 H10 N O6 P Name PYRIDOXAL-5'-PHOSPHATE; VITAMIN B6 Phosphate ChEMBL CHEMBL82202 DrugBank DB00114 ZINC ZINC000001532514 PDB chain 1pmm Chain C Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 1pmm Crystal structure and functional analysis of escherichia coli glutamate decarboxylase Resolution 2.0 Å Binding residue (original residue number in PDB) S126 S127 Q163 T212 D243 A245 H275 K276 Binding residue (residue number reindexed from 1) S123 S124 Q160 T209 D240 A242 H272 K273 Annotation score 1

Enzymatic activity Enzyme Commision number 4.1.1.15: glutamate decarboxylase.

Gene Ontology Molecular Function GO:0004351 glutamate decarboxylase activity GO:0005515 protein binding GO:0016830 carbon-carbon lyase activity GO:0016831 carboxy-lyase activity GO:0030170 pyridoxal phosphate binding

	Biological Process
GO:0006536	glutamate metabolic process
GO:0006538	glutamate catabolic process
GO:0019752	carboxylic acid metabolic process
GO:0051454	intracellular pH elevation

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane

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