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Structure of PDB 7x06 Chain B Binding Site BS01

Receptor Information >7x06 Chain B (length=804) Species: 1094619 (Phytophthora sojae strain P6497) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] PPPSIRSCGSQQYVTSYIPTGAAFPPSSVQDMISSMKSYASATDLVRTYS EIPSVEEALSTLDRAAAALNARRYRDALKLYLEGGYAMANVAERQANPKI CNLLTSKGFETLNWCARLCDWIEGRIKEKHPRPGVHKVGIPVSNWDEDWV GPFMDEEEARRMWYTPVYCPHPIDFSNLGYRLRCVETGRRPRLMICITMY NEGPQQLKATLKKLANNLAYLKEQMPGDEKSLTGAFAGDDVWQNVLVCIV ADGREQVHPKTLDYLEAIGLYDEDLLTINSAGIGAQCHLFEHTLQLSVNG KCLLPIQTVFALKENKASKLDSHHWYFNAFAEQIQPEYTAVMDVGTMLTK SALYHLLFAFERNHQIGGACGQLTVDNPFENLSNWVISAQHFEYKISNIL DKSLESCFGFISVLPGAFSAYRYEAIRGAPLDAYFQTLNIELDVLGPFIG NMYLAEDRILSFEVVARKNCNWTMHYVKDAVARTDVPHDLVGLISQRKRW LNGAFFATLFSIWNWGRIYSESKHTFVRKMAFLVFYVYHLLYTAFGFFLP ANLYLALFFIVFQGFQQNRLEFIDTSEYSQTVLDCAVYIYNFSYLFGLLM LIIIGLGNNPKHMKLTYYFVGAVFGLMMMLSSLVGAGIFFSTPATVHSIV VSILTVGVYFIASALHGEVHHIFMTFTHYTALIPSFVNIFTIYSFCNLQD LSETEKGDFKDVIAKRRALEELRREEKERVENRKKNFEAFRTNVLLTWAF SNLIFALFVVYFASSSTYMPVLYIFVASLNTCRLLGSIGHWVYIHTEGLR GRVI

Ligand information Ligand ID UDP InChI InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1 InChIKey XCCTYIAWTASOJW-XVFCMESISA-N SMILES Software SMILES OpenEye OEToolkits 1.7.0 C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO[P@@](=O)(O)OP(=O)(O)O)O)O CACTVS 3.370 O[CH]1[CH](O)[CH](O[CH]1CO[P](O)(=O)O[P](O)(O)=O)N2C=CC(=O)NC2=O CACTVS 3.370 O[C@H]1[C@@H](O)[C@@H](O[C@@H]1CO[P](O)(=O)O[P](O)(O)=O)N2C=CC(=O)NC2=O OpenEye OEToolkits 1.7.0 C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)O)O)O ACDLabs 12.01 O=P(O)(O)OP(=O)(O)OCC2OC(N1C(=O)NC(=O)C=C1)C(O)C2O Formula C9 H14 N2 O12 P2 Name URIDINE-5'-DIPHOSPHATE ChEMBL CHEMBL130266 DrugBank DB03435 ZINC ZINC000004490939 PDB chain 7x06 Chain B Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 7x06 Structural basis for directional chitin biosynthesis. Resolution 3.1 Å Binding residue (original residue number in PDB) T237 Y239 E241 D291 K358 D382 R538 Binding residue (residue number reindexed from 1) T198 Y200 E202 D252 K319 D343 R499 Annotation score 3

Enzymatic activity Enzyme Commision number 2.4.1.16: chitin synthase.

Gene Ontology Molecular Function GO:0004100 chitin synthase activity GO:0016757 glycosyltransferase activity GO:0016758 hexosyltransferase activity

	Biological Process
GO:0006031	chitin biosynthetic process
GO:0071555	cell wall organization

	Cellular Component
GO:0005886	plasma membrane
GO:0030428	cell septum
GO:0071944	cell periphery

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