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BioLiP

Structure of PDB 6urq Chain B Binding Site BS01

Receptor Information
>6urq Chain B (length=307) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRI
VQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLW
QFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERL
TYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLH
PKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKM
NALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEA
VQQILSE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6urq Tissue-Specific Regulation of the Wnt/ beta-Catenin Pathway by PAGE4 Inhibition of Tankyrase.
Resolution2.05 Å
Binding residue
(original residue number in PDB)		R368 S370 G378 Y379 N408 Y412 H414 D432 W434 F436 E441 R447
Binding residue
(residue number reindexed from 1)		R34 S36 G44 Y45 N74 Y78 H80 D98 W100 F102 E107 R113
Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
External links
PDB RCSB:6urq, PDBe:6urq, PDBj:6urq
PDBsum6urq
PubMed32698014
UniProtO95271|TNKS1_HUMAN Poly [ADP-ribose] polymerase tankyrase-1 (Gene Name=TNKS)

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