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Structure of PDB 2h6i Chain B Binding Site BS01

Receptor Information >2h6i Chain B (length=410) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] SSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKF NHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPTLCYWILHSLELL DEPIPQIVATDVCQFLELCQSPEGGFGGGPGQYPHLAPTYAAVNALCIIG TEEAYDIINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLT NIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKR ERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRA LHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTC FCLSGLSIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQATTY FLQKPVPGFE

Ligand information >2h6i Chain P (length=4) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure] CVLS

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 2h6i Conversion of protein farnesyltransferase to a geranylgeranyltransferase. Resolution 3.0 Å Binding residue (original residue number in PDB) R702 Y861 H862 Binding residue (residue number reindexed from 1) R188 Y347 H348

Enzymatic activity Catalytic site (original residue number in PDB) H748 R791 K794 D797 C799 Y800 D852 D859 H862 Catalytic site (residue number reindexed from 1) H234 R277 K280 D283 C285 Y286 D338 D345 H348 Enzyme Commision number 2.5.1.58: protein farnesyltransferase.

Gene Ontology Molecular Function GO:0003824 catalytic activity GO:0004659 prenyltransferase activity GO:0004660 protein farnesyltransferase activity GO:0005515 protein binding GO:0008270 zinc ion binding GO:0008318 protein prenyltransferase activity GO:0046872 metal ion binding

	Biological Process
GO:0006629	lipid metabolic process
GO:0018343	protein farnesylation

	Cellular Component
GO:0005829	cytosol
GO:0005875	microtubule associated complex
GO:0005965	protein farnesyltransferase complex

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