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Structure of PDB 1dfp Chain B Binding Site BS01

Receptor Information >1dfp Chain B (length=228) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] ILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGK VQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKAT LGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLD RATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSG SRVCGNRKKPGIYTRVASYAAWIDSVLA

Ligand information Ligand ID DFP InChI InChI=1S/C6H15O3P/c1-5(2)8-10(7)9-6(3)4/h5-6,10H,1-4H3 InChIKey BLKXLEPPVDUHBY-UHFFFAOYSA-N SMILES Software SMILES CACTVS 3.341 CC(C)O[PH](=O)OC(C)C OpenEye OEToolkits 1.5.0 CC(C)OP(=O)OC(C)C ACDLabs 10.04 O=P(OC(C)C)OC(C)C Formula C6 H15 O3 P Name DIISOPROPYL PHOSPHONATE ChEMBL DrugBank DB04491 ZINC ZINC000100018862 PDB chain 1dfp Chain B Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 1dfp Structure of diisopropyl fluorophosphate-inhibited factor D. Resolution 2.4 Å Binding residue (original residue number in PDB) K192 G193 S195 S215 G216 Binding residue (residue number reindexed from 1) K180 G181 S183 S199 G200 Annotation score 1

Enzymatic activity Catalytic site (original residue number in PDB) H57 D102 K192 G193 D194 S195 G196 Catalytic site (residue number reindexed from 1) H41 D89 K180 G181 D182 S183 G184 Enzyme Commision number 3.4.21.46: complement factor D.

Gene Ontology Molecular Function GO:0004252 serine-type endopeptidase activity GO:0008236 serine-type peptidase activity

	Biological Process
GO:0006508	proteolysis
GO:0006956	complement activation
GO:0006957	complement activation, alternative pathway
GO:0009617	response to bacterium

	Cellular Component
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0031093	platelet alpha granule lumen
GO:0034774	secretory granule lumen
GO:0070062	extracellular exosome
GO:1904813	ficolin-1-rich granule lumen

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