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Structure of PDB 8r18 Chain A Binding Site BS01

Receptor Information >8r18 Chain A (length=273) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] PLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPN GTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDF ITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGEL KLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILL YDMVCGDIPFEHDEEIIGGQVFFRQRVSSECQHLIRWCLALRPSDRPTFE EIQNHPWMQDVLLPQETAEIHLH

Ligand information >8r18 Chain C (length=10) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure] ARKRRRHPSG

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 8r18 Pim1 in complex with (E)-4-(4-hydroxystyryl)benzoic acid and Pimtide Resolution 1.89 Å Binding residue (original residue number in PDB) D128 F130 D131 I133 T134 D167 D170 E171 D202 G203 T204 V206 G238 D239 E243 Binding residue (residue number reindexed from 1) D96 F98 D99 I101 T102 D135 D138 E139 D170 G171 T172 V174 G206 D207 E211

Enzymatic activity Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.

Gene Ontology Molecular Function GO:0004672 protein kinase activity GO:0004674 protein serine/threonine kinase activity GO:0005515 protein binding GO:0005524 ATP binding GO:0008134 transcription factor binding GO:0030145 manganese ion binding GO:0043024 ribosomal small subunit binding GO:0044024 histone H2AS1 kinase activity GO:0046872 metal ion binding GO:0106310 protein serine kinase activity

	Biological Process
GO:0006338	chromatin remodeling
GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0016310	phosphorylation
GO:0022898	regulation of transmembrane transporter activity
GO:0043066	negative regulation of apoptotic process
GO:0043433	negative regulation of DNA-binding transcription factor activity
GO:0045824	negative regulation of innate immune response
GO:0045893	positive regulation of DNA-templated transcription
GO:0046777	protein autophosphorylation
GO:0050821	protein stabilization
GO:0060045	positive regulation of cardiac muscle cell proliferation
GO:0070561	vitamin D receptor signaling pathway
GO:0071346	cellular response to type II interferon
GO:0090336	positive regulation of brown fat cell differentiation
GO:1902033	regulation of hematopoietic stem cell proliferation
GO:1904263	positive regulation of TORC1 signaling
GO:1905062	positive regulation of cardioblast proliferation
GO:1990748	cellular detoxification

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane

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