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Structure of PDB 8hg7 Chain A Binding Site BS01

Receptor Information >8hg7 Chain A (length=590) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] DNPADILVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGRSMVWWPVGAS LFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFAPVYLTA GVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQAL GWNIYASVIALLGITMIYTVTGGLAALMYTDTVQTFVILGGACILMGYAF HEVGGYSGLFDKYLGAATSLTVSEDPAVGNISSFCYRPRPDSYHLLRHPV TGDLPWPALLLGLTIVSGWYWCSDQVIVQRCLAGKSLTHIKAGCILCGYL KLTPMFLMVMPGMISRILYPDEVACVVPEVCRRVCGTEVGCSNIAYPRLV VKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDR ELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAV FVLALFVPRVNEQGAFWGLIGGLLMGLARLIPEFSFGSGSCVQPSACPAF LCGVHYLYFAIVLFFCSGLLTLTVSLCTAPIPRKHLHRLVFSLRHSKEER EDLDARRLEDISEDPSWARVVNLNALLMMAVAVFLWGFYA

Ligand information >8hg7 Chain B (length=29) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure] QPWMQGLIAVAVFLVLVAIAFAVNHFWCQ

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 8hg7 Structural basis of glucose transport by the human SGLT2-MAP17 glucose transporter Resolution 3.1 Å Binding residue (original residue number in PDB) M661 V665 F666 G669 F670 Binding residue (residue number reindexed from 1) M579 V583 F584 G587 F588

Enzymatic activity Enzyme Commision number ?

Gene Ontology Molecular Function GO:0005362 low-affinity D-glucose:sodium symporter activity GO:0005412 D-glucose:sodium symporter activity GO:0005515 protein binding GO:0015151 alpha-glucoside transmembrane transporter activity GO:0015293 symporter activity GO:0015370 solute:sodium symporter activity GO:0022857 transmembrane transporter activity GO:0055056 D-glucose transmembrane transporter activity

	Biological Process
GO:0000017	alpha-glucoside transport
GO:0005975	carbohydrate metabolic process
GO:0006814	sodium ion transport
GO:0008645	hexose transmembrane transport
GO:0035623	renal D-glucose absorption
GO:0055085	transmembrane transport
GO:0098708	D-glucose import across plasma membrane
GO:0098719	sodium ion import across plasma membrane

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016324	apical plasma membrane
GO:0070062	extracellular exosome

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