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BioLiP

Structure of PDB 7q5x Chain A Binding Site BS01

Receptor Information
>7q5x Chain A (length=221) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFT
DGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGK
LGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDA
KVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAI
TVWYFDADERARAKVKYLTGE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7q5x Structural basis for binding of the renal carcinoma target hypoxia-inducible factor 2 alpha to prolyl hydroxylase domain 2.
Resolution1.21 Å
Binding residue
(original residue number in PDB)		Q239 L240 V241 S242 K244 R252 W258 D277 R281 N293 G294 R295 Y310 H313 V314 D315 P317 N318 R322 W389 F391 R396 K400
Binding residue
(residue number reindexed from 1)		Q53 L54 V55 S56 K58 R66 W72 D91 R95 N107 G108 R109 Y124 H127 V128 D129 P131 N132 R136 W203 F205 R210 K214
Enzymatic activity
Enzyme Commision number 1.14.11.29: hypoxia-inducible factor-proline dioxygenase.
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0031418 L-ascorbic acid binding

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Molecular Function
External links
PDB RCSB:7q5x, PDBe:7q5x, PDBj:7q5x
PDBsum7q5x
PubMed37449559
UniProtQ9GZT9|EGLN1_HUMAN Egl nine homolog 1 (Gene Name=EGLN1)

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