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Structure of PDB 7dbm Chain A Binding Site BS01

Receptor Information
>7dbm Chain A (length=552) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIG
PENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLK
QKKSVTVLDVGDAFYSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPM
GWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRTK
IEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDS
WTVNDIQKLVGKLNWASQIYAGIKVRQLSKLLRGTKALTEVVPLTEEAEL
ELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKT
GKYARMKGAHTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWEAW
WTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIIGAETFYVDGAANRETK
LGKAGYVTDRGRQKVVPLTDTTNQKTELQAIHLALQDSGLEVNIVTDSQY
ALGIIQAQPDKSESELVSQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKL
VS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7dbm Biochemical and Structural Properties of Entecavir-Resistant Hepatitis B Virus Polymerase with L180M/M204V Mutations.
Resolution2.43 Å
Binding residue
(original residue number in PDB)		W24 F61 L74 D76 R78 E89 Q91 I94 G152 K154 P157 Y183 V184 D185 M230 G231 N255 Q258 K259 G262 K263 W266 S280 R284 G285 K353 H361 K374 R448 T473 Q475 Y501
Binding residue
(residue number reindexed from 1)		W23 F60 L73 D75 R77 E88 Q90 I93 G151 K153 P156 Y182 V183 D184 M229 G230 N254 Q257 K258 G261 K262 W265 S279 R283 G284 K352 H360 K373 R447 T472 Q474 Y500
Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003964 RNA-directed DNA polymerase activity
GO:0004523 RNA-DNA hybrid ribonuclease activity
Biological Process
GO:0006278 RNA-templated DNA biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7dbm, PDBe:7dbm, PDBj:7dbm
PDBsum7dbm
PubMed34076480
UniProtP12497|POL_HV1N5 Gag-Pol polyprotein (Gene Name=gag-pol)

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