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BioLiP

Structure of PDB 6iu7 Chain A Binding Site BS01

Receptor Information
>6iu7 Chain A (length=422) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKF
VSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASP
HAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTLACG
YLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADSCWA
ISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVTGT
DEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVV
NHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEP
LMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIE
ALQRHENESVYKASLNLIEKYF
Ligand information
>6iu7 Chain B (length=22) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
SGKRKLITSEEERSPAKRGRKS
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6iu7 Structural and biochemical characterization of the recognition of the 53BP1 nuclear localization signal by importin-alpha.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		S105 F138 W142 N146 S149 G150 T151 T155 Q181 W184 N188 G191 D192 W231 R238 D270 W273 Y277 G281 R315 V321 T322 W357 N361 E396 W399
Binding residue
(residue number reindexed from 1)		S31 F64 W68 N72 S75 G76 T77 T81 Q107 W110 N114 G117 D118 W157 R164 D196 W199 Y203 G207 R241 V247 T248 W283 N287 E322 W325
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:6iu7, PDBe:6iu7, PDBj:6iu7
PDBsum6iu7
PubMed30685087
UniProtP52293|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

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