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BioLiP

Structure of PDB 5k97 Chain A Binding Site BS01

Receptor Information
>5k97 Chain A (length=341) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGD
VLQNEEGETTSHLMGMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKRS
ERRAEAEKQLQQAQAAGAEQEVEKFTKRLVKVTKQHNDECKHLLSLMGIP
YLDAPSEAEASCAALVKAGKVYAAATEDMDCLTFGSPVLMRHLTASEAKK
LPIQEFHLSRILQELGLNQEQFVDLCILLGSNYCESIRGIGPKRAVDLIQ
KHKSIEEIVRRLDPNKYPVPENWLHKEAHQLFLEPEVLDPESVELKWSEP
NEEELIKFMCGEKQFSEERIRSGVKRLSKSRQGSTLEVLFQ
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5k97 Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability.
Resolution2.102 Å
Binding residue
(original residue number in PDB)		I44 A45 V46 Y69 R70 R73 K128 R239 G240 G242 K244 R245
Binding residue
(residue number reindexed from 1)		I43 A44 V45 Y68 R69 R72 K127 R238 G239 G241 K243 R244
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0004518 nuclease activity
GO:0016788 hydrolase activity, acting on ester bonds

View graph for
Molecular Function
External links
PDB RCSB:5k97, PDBe:5k97, PDBj:5k97
PDBsum5k97
PubMed28653660
UniProtP39748|FEN1_HUMAN Flap endonuclease 1 (Gene Name=FEN1)

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