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BioLiP

Structure of PDB 4gz0 Chain A Binding Site BS01

Receptor Information
>4gz0 Chain A (length=250) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSTISFITWNIDGLDGCNLPERARGVCSCLALYSPDVVFLQEVIPPYCAY
LKKRAASYTIITGNEEGYFTAILLKKGRVKFKSQEIIPFPNTKMMRNLLC
VNVSLGGNEFCLMTSHLESTREHSAERIRQLKTVLGKMQEAPDSTTVIFA
GDTNLRDQEVIKCGGLPDNVFDAWEFLGKPKHCQYTWDTKANNNLRIPAA
YKHRFDRIFFRAEEGHLIPQSLDLVGLEKLDCGRFPSDHWGLLCTLNVVL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4gz0 Mechanism of repair of 5'-topoisomerase II-DNA adducts by mammalian tyrosyl-DNA phosphodiesterase 2.
Resolution2.113 Å
Binding residue
(original residue number in PDB)		D132 H236 S239 T240 R241 N274 R276 W307 L315 I317 Y321
Binding residue
(residue number reindexed from 1)		D12 H116 S119 T120 R121 N154 R156 W187 L195 I197 Y201
Enzymatic activity
Enzyme Commision number 3.1.4.-
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:4gz0, PDBe:4gz0, PDBj:4gz0
PDBsum4gz0
PubMed23104055
UniProtQ9JJX7|TYDP2_MOUSE Tyrosyl-DNA phosphodiesterase 2 (Gene Name=Tdp2)

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