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BioLiP

Structure of PDB 3pmo Chain A Binding Site BS01

Receptor Information
>3pmo Chain A (length=357) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSHHHHHHSSGLVPRGSHMSTLSYTLGQLAAHVGAEVRGDADLPIQGLAT
LQEAGPAQLSFLANPQYRKYLPESRAGAVLLTAADADGFAGTALVVANPY
LAYASLSHLFDRKPKAAAGIHPTAIVAADAEVDPSASVGAYAVIESGARI
GAGVSIGAHCVIGARSVIGEGGWLAPRVTLYHDVTIGARVSIQSGAVIGG
EGFGFANEKGVWQKIAQIGGVTIGDDVEIGANTTIDRGALSDTLIGNGVK
LDNQIMIAHNVQIGDHTAMAACVGISGSAKIGRHCMLAGGVGLVGHIEIC
DNVFVTGMTMVTRSITEPGSYSSGTAMQPAAEWKKSAARIRQLDDMARRL
QQLEKRL
Ligand information
Ligand IDCL
InChIInChI=1S/ClH/h1H/p-1
InChIKeyVEXZGXHMUGYJMC-UHFFFAOYSA-M
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Cl-]
FormulaCl
NameCHLORIDE ION
ChEMBL
DrugBankDB14547
ZINC
PDB chain3pmo Chain A Residue 356 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3pmo The structure of LpxD from Pseudomonas aeruginosa at 1.3 A resolution.
Resolution1.3 Å
Binding residue
(original residue number in PDB)		R-2 A46 Y50
Binding residue
(residue number reindexed from 1)		R15 A63 Y67
Annotation score1
Enzymatic activity
Enzyme Commision number 2.3.1.191: UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase.
Gene Ontology
Molecular Function
GO:0016410 N-acyltransferase activity
GO:0016740 transferase activity
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
Biological Process
GO:0009245 lipid A biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3pmo, PDBe:3pmo, PDBj:3pmo
PDBsum3pmo
PubMed21795786
UniProtQ9HXY6|LPXD_PSEAE UDP-3-O-acylglucosamine N-acyltransferase (Gene Name=lpxD)

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