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BioLiP

Structure of PDB 3p8f Chain A Binding Site BS01

Receptor Information
>3p8f Chain A (length=241) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYIDDRGF
RYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIAL
LELEKPAEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQ
KGEIRVIQQTTCENLLPQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEA
DGRIFQAGVVSWGDGCAQRNKPGVYTRLPLFRDWIKENTGV
Ligand information
Receptor-Ligand Complex Structure
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PDB3p8f Structure of catalytic domain of Matriptase in complex with Sunflower trypsin inhibitor-1.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		I41 H57 F97 F99 Q175 S190 C191 Q192 G193 S195 V213 S214 W215 G216
Binding residue
(residue number reindexed from 1)		I26 H42 F92 F94 Q169 S186 C187 Q188 G189 S191 V210 S211 W212 G213
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 Q192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H42 D97 Q188 G189 D190 S191 G192
Enzyme Commision number 3.4.21.109: matriptase.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3p8f, PDBe:3p8f, PDBj:3p8f
PDBsum3p8f
PubMed21693064
UniProtQ9Y5Y6|ST14_HUMAN Suppressor of tumorigenicity 14 protein (Gene Name=ST14)

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