BioLiP

Structure of PDB 3g6y Chain A Binding Site BS01

Receptor Information

>3g6y Chain A (length=373) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

ASSRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLG
VKKLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLG
FDENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLL
VGSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPE
SCQHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELG
ISVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEEL
LASLLNRVCQDGRKPHTVRLIIRRYSSEKHYGRESRQCPIPSHVIQVMTP
MVDILMKLFRNMTLLSVCFCNLK

Ligand information

>3g6y Chain P (length=7) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

aggaccc

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3g6y DNA Synthesis across an Abasic Lesion by Human DNA Polymerase iota
Resolution	2.1 Å
Binding residue (original residue number in PDB)	E127 K207 G243 Y244 K245 T246 S359
Binding residue (residue number reindexed from 1)	E103 K183 G219 Y220 K221 T222 S335

Enzymatic activity

Enzyme Commision number

2.7.7.7: DNA-directed DNA polymerase.

Gene Ontology

	Molecular Function
GO:0003684	damaged DNA binding
GO:0003887	DNA-directed DNA polymerase activity

	Biological Process
GO:0006281	DNA repair

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Molecular Function

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Biological Process

PDB	RCSB:3g6y, PDBe:3g6y, PDBj:3g6y
PDBsum	3g6y
PubMed	19368886
UniProt	Q9UNA4\|POLI_HUMAN DNA polymerase iota (Gene Name=POLI)