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Structure of PDB 2xum Chain A Binding Site BS01

Receptor Information >2xum Chain A (length=349) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] MAATAAEAVASGSGEPREEAGALGPAWDESQLRSYSFPTRPIPRLSQSDP RAEELIENEEPVVLTDTNLVYPALKWDLEYLQENIGNGDFSVYSASTHKF LYYDEKKMANFQNFKPRSNREEMKFHEFVEKLQDIQQRGGEERLYLQQTL NDTVGRKIVMDFLGFNWNWINKQQGKRGWGQLTSNLLLIGMEGNVTPAHY DEQQNFFAQIKGYKRCILFPPDQFECLYPYPVHHPCDRHSQVDFDNPDYE RFPNFQNVVGYETVVGPGDVLYIPMYWWHHIESLLNGGITITVNFWYKGA PTPKRIEYPLKAHQKVAIMRNIEKMLGEALGNPQEVGPLLNTMIKGRYN

Ligand information >2xum Chain S (length=18) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure] EVVKLLLEHGADVDAQDK

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 2xum Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor. Resolution 2.2 Å Binding residue (original residue number in PDB) Y102 E105 T183 S184 H199 D201 E202 Q203 R238 H239 W296 K304 I306 I318 N321 M325 Binding residue (residue number reindexed from 1) Y102 E105 T183 S184 H199 D201 E202 Q203 R238 H239 W296 K304 I306 I318 N321 M325

Enzymatic activity Enzyme Commision number 1.14.11.30: hypoxia-inducible factor-asparagine dioxygenase. 1.14.11.n4: ankyrin-repeat-histidine dioxagenase.

Gene Ontology Molecular Function GO:0003714 transcription corepressor activity GO:0005112 Notch binding GO:0005515 protein binding GO:0008198 ferrous iron binding GO:0008270 zinc ion binding GO:0019826 oxygen sensor activity GO:0031406 carboxylic acid binding GO:0036139 peptidyl-histidine dioxygenase activity GO:0036140 [protein]-asparagine 3-dioxygenase activity GO:0042803 protein homodimerization activity GO:0046872 metal ion binding GO:0051059 NF-kappaB binding GO:0051213 dioxygenase activity GO:0062101 peptidyl-aspartic acid 3-dioxygenase activity GO:0071532 ankyrin repeat binding

	Biological Process
GO:0045663	positive regulation of myoblast differentiation
GO:0045746	negative regulation of Notch signaling pathway
GO:0045892	negative regulation of DNA-templated transcription
GO:2001214	positive regulation of vasculogenesis

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0048471	perinuclear region of cytoplasm

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