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BioLiP

Structure of PDB 2a9i Chain A Binding Site BS01

Receptor Information
>2a9i Chain A (length=105) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPLTPSTYIRNLNVGILRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFH
IRRFEALLQTGLSPTCELLFDWGTTNCTVGDLVDLLVQIELFAPATLLLP
DAVPQ
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain2a9i Chain A Residue 114 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2a9i Cutting Edge: Molecular Structure of the IL-1R-Associated Kinase-4 Death Domain and Its Implications for TLR Signaling.
Resolution1.7 Å
Binding residue
(original residue number in PDB)		K21 D24
Binding residue
(residue number reindexed from 1)		K19 D22
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Gene Ontology
Biological Process
GO:0007165 signal transduction

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Biological Process
External links
PDB RCSB:2a9i, PDBe:2a9i, PDBj:2a9i
PDBsum2a9i
PubMed16177054
UniProtQ8R4K2|IRAK4_MOUSE Interleukin-1 receptor-associated kinase 4 (Gene Name=Irak4)

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