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Structure of PDB 1hqc Chain A Binding Site BS01

Receptor Information >1hqc Chain A (length=314) Species: 274 (Thermus thermophilus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] ALRPKTLDEYIGQERLKQKLRVYLEAAKARKEPLEHLLLFGPPGLGKTTL AHVIAHELGVNLRVTSGPAIEKPGDLAAILANSLEEGDILFIDEIHRLSR QAEEHLYPAMEDFVMDIVIGQGPAARTIRLELPRFTLIGATTRPGLITAP LLSRFGIVEHLEYYTPEELAQGVMRDARLLGVRITEEAALEIGRRSRGTM RVAKRLFRRVRDFAQVAGEEVITRERALEALAALGLDELGLEKRDREILE VLILRFGGGPVGLATLATALSEDPGTLEEVHEPYLIRQGLLKRTPRGRVP TELAYRHLGYPPPV

Ligand information Ligand ID ADE InChI InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) InChIKey GFFGJBXGBJISGV-UHFFFAOYSA-N SMILES Software SMILES CACTVS 3.341 Nc1ncnc2[nH]cnc12 OpenEye OEToolkits 1.5.0 c1[nH]c2c(n1)c(ncn2)N ACDLabs 10.04 n1c(c2ncnc2nc1)N Formula C5 H5 N5 Name ADENINE ChEMBL CHEMBL226345 DrugBank DB00173 ZINC ZINC000000000882 PDB chain 1hqc Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 1hqc Crystal structure of the Holliday junction migration motor protein RuvB from Thermus thermophilus HB8. Resolution 3.2 Å Binding residue (original residue number in PDB) Y14 I15 Binding residue (residue number reindexed from 1) Y10 I11 Annotation score 1

Enzymatic activity Catalytic site (original residue number in PDB) K51 T52 D97 T146 R205 Catalytic site (residue number reindexed from 1) K47 T48 D93 T142 R201 Enzyme Commision number 3.6.4.12: DNA helicase.

Gene Ontology Molecular Function GO:0000400 four-way junction DNA binding GO:0003677 DNA binding GO:0005524 ATP binding GO:0009378 four-way junction helicase activity GO:0016787 hydrolase activity GO:0016887 ATP hydrolysis activity

	Biological Process
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0032508	DNA duplex unwinding

	Cellular Component
GO:0005737	cytoplasm
GO:0048476	Holliday junction resolvase complex

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