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Structure of PDB 1fnm Chain A Binding Site BS01

Receptor Information >1fnm Chain A (length=655) Species: 274 (Thermus thermophilus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] EYDLKRLRNIGIAAHIDAGKTTTTERILYYTGRIAVTTCFWKDHRINIID TPGHVDFTIEVERSMRVLDGAIVVFDSSQGVEPQSETVWRQAEKYKVPRI AFANKMDKTGADLWLVIRTMQERLGARPVVMQLPIGREDTFSGIIDVLRM KAYTYGNDLGTDIREIPIPEEYLDQAREYHEKLVEVAADFDENIMLKYLE GEEPTEEELVAAIRKGTIDLKITPVFLGSALKNKGVQLLLDAVVDYLPSP LDIPPIKGTTPEGEVVEIHPDPNGPLAALAFKIMADPYVGRLTFIRVYSG TLTSGSYVYNTTKGRKERVARLLRMHANHREEVEELKAGDLGAVVGLKET ITGDTLVGEDAPRVILESIEVPEPVIDVAIEPKTKADQEKLSQALARLAE EDPTFRVSTHPETGQTIISGMGELHLEIIVDRLKREFKVDANVGKPQVAY RETITKPVDVEGKFIRQTGGRGQYGHVKIKVEPLPRGSGFEFVNAIVGGV IPKEYIPAVQKGIEEAMQSGPLIGFPVVDIKVTLYDGSYAEVDSSEMAFK IAGSMAIKEAVQKGDPVILEPIMRVEVTTPEEYMGDVIGDLNARRGQILG MEPRGNAQVIRAFVPLAEMFGYATDLRSKTQGRGSFVMFFDHYQEVPKQV QEKLI

Ligand information Ligand ID GDP InChI InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1 InChIKey QGWNDRXFNXRZMB-UUOKFMHZSA-N SMILES Software SMILES OpenEye OEToolkits 1.7.6 c1nc2c(n1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N CACTVS 3.385 NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@H](CO[P](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O CACTVS 3.385 NC1=Nc2n(cnc2C(=O)N1)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O ACDLabs 12.01 O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c2N=C(N)NC1=O)C(O)C3O OpenEye OEToolkits 1.7.6 c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N Formula C10 H15 N5 O11 P2 Name GUANOSINE-5'-DIPHOSPHATE ChEMBL CHEMBL384759 DrugBank DB04315 ZINC ZINC000008215481 PDB chain 1fnm Chain A Residue 900 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 1fnm Structure of a mutant EF-G reveals domain III and possibly the fusidic acid binding site. Resolution 2.8 Å Binding residue (original residue number in PDB) D22 G24 K25 T26 T27 N137 K138 D140 S262 L264 Binding residue (residue number reindexed from 1) D17 G19 K20 T21 T22 N104 K105 D107 S229 L231 Annotation score 4

Enzymatic activity Catalytic site (original residue number in PDB) D22 Catalytic site (residue number reindexed from 1) D17 Enzyme Commision number ?

Gene Ontology Molecular Function GO:0000287 magnesium ion binding GO:0003746 translation elongation factor activity GO:0003924 GTPase activity GO:0005525 GTP binding GO:0019003 GDP binding GO:0043022 ribosome binding

	Biological Process
GO:0006412	translation
GO:0006414	translational elongation
GO:0032790	ribosome disassembly

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol

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