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Structure of PDB 1b1x Chain A Binding Site BS01

Receptor Information >1b1x Chain A (length=689) Species: 9796 (Equus caballus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] APRKSVRWCTISPAEAAKCAKFQRNMKKVRGPSVSCIRKTSSFECIQAIA ANKADAVTLDGGLVYEAGLHPYKLRPVAAEVYQTRGKPQTRYYAVAVVKK GSGFQLNQLQGVKSCHTGLGRSAGWNIPIGTLRPYLNWTGPPEPLQKAVA NFFSASCVPCADGKQYPNLCRLCAGTEADKCACSSQEPYFGYSGAFKCLE NGAGDVAFVKDSTVFENLPDEAERDKYELLCPDNTRKPVDAFKECHLARV PSHAVVARSVDGREDLIWKLLHRAQEEFGRNKSSAFQLFGSTPGEQDLLF KDSALGFVRIPSQIDSGLYLGANYLTATQNLRETAAEVAARRERVVWCAV GPEEERKCKQWSDVSNRKVACASASTTEECIALVLKGEADALNLDGGFIY VAGKCGLVPVLAENQKSQNSNAPDCVHRPPEGYLAVAVVRKSDADLTWNS LSGKKSCHTGVGRTAAWNIPMGLLFNQTGSCKFDKFFSQSCAPGADPQSS LCALCVGNNENENKCMPNSEERYYGYTGAFRCLAEKAGDVAFVKDVTVLQ NTDGKNSEPWAKDLKQEDFELLCLDGTRKPVAEAESCHLARAPNHAVVSQ SDRAQHLKKVLFLQQDQFGGNGPDCPGKFCLFKSETKNLLFNDNTECLAE LQGKTTYEQYLGSEYVTSITNLRRCSSSPLLEACAFLRA

Ligand information Ligand ID FE InChI InChI=1S/Fe/q+3 InChIKey VTLYFUHAOXGGBS-UHFFFAOYSA-N SMILES Software SMILES ACDLabs 10.04 CACTVS 3.341 OpenEye OEToolkits 1.5.0 [Fe+3] Formula Fe Name FE (III) ION ChEMBL DrugBank DB13949 ZINC PDB chain 1b1x Chain A Residue 690 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 1b1x Three-dimensional structure of mare diferric lactoferrin at 2.6 A resolution. Resolution 2.62 Å Binding residue (original residue number in PDB) D60 Y92 Y192 H253 Binding residue (residue number reindexed from 1) D60 Y92 Y192 H253 Annotation score 4

Enzymatic activity Enzyme Commision number 3.4.21.-

Gene Ontology Molecular Function GO:0008236 serine-type peptidase activity GO:0046872 metal ion binding

	Biological Process
GO:0001503	ossification
GO:0001817	regulation of cytokine production
GO:0002227	innate immune response in mucosa
GO:0002376	immune system process
GO:0006508	proteolysis
GO:0006826	iron ion transport
GO:0019731	antibacterial humoral response
GO:0019732	antifungal humoral response
GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway
GO:0032680	regulation of tumor necrosis factor production
GO:0033690	positive regulation of osteoblast proliferation
GO:0043066	negative regulation of apoptotic process
GO:0045669	positive regulation of osteoblast differentiation
GO:0060349	bone morphogenesis
GO:1900159	positive regulation of bone mineralization involved in bone maturation
GO:1900229	negative regulation of single-species biofilm formation in or on host organism
GO:1902732	positive regulation of chondrocyte proliferation
GO:2000308	negative regulation of tumor necrosis factor (ligand) superfamily member 11 production
GO:2001205	negative regulation of osteoclast development

	Cellular Component
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005769	early endosome
GO:0005886	plasma membrane
GO:0042581	specific granule
GO:0055037	recycling endosome

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