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Structure of PDB 1avr Chain A Binding Site BS01

Receptor Information >1avr Chain A (length=316) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] QVLRGTVTDFPGFDERADAETLRKAMKGLGTDEESILTLLTSRSNAQRQE ISAAFKTLFGRDLLDDLKSELTGKFEKLIVALMKPSRLYDAYELKHALKG AGTNEKVLTEIIASRTPEELRAIKQVYEEEYGSSLEDDVVGDTSGYYQRM LVVLLQANRDPDAGIDEAQVEQDAQALFQAGELKWGTDEEKFITIFGTRS VSHLRKVFDKYMTISGFQIEETIDRETSGNLEQLLLAVVKSIRSIPAYLA ETLYYAMKGAGTDDHTLIRVMVSRSEIDLFNIRKEFRKNFATSLYSMIKG DTSGDYKKALLLLCGE

Ligand information Ligand ID CA InChI InChI=1S/Ca/q+2 InChIKey BHPQYMZQTOCNFJ-UHFFFAOYSA-N SMILES Software SMILES CACTVS 3.341 [Ca++] ACDLabs 10.04 OpenEye OEToolkits 1.5.0 [Ca+2] Formula Ca Name CALCIUM ION ChEMBL DrugBank DB14577 ZINC PDB chain 1avr Chain A Residue 321 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 1avr Crystal and molecular structure of human annexin V after refinement. Implications for structure, membrane binding and ion channel formation of the annexin family of proteins. Resolution 2.3 Å Binding residue (original residue number in PDB) L100 G102 G104 D144 E318 Binding residue (residue number reindexed from 1) L98 G100 G102 D142 E316 Annotation score 4

Enzymatic activity Enzyme Commision number ?

Gene Ontology Molecular Function GO:0001786 phosphatidylserine binding GO:0004859 phospholipase inhibitor activity GO:0005509 calcium ion binding GO:0005515 protein binding GO:0005543 phospholipid binding GO:0005544 calcium-dependent phospholipid binding

	Biological Process
GO:0007165	signal transduction
GO:0007596	blood coagulation
GO:0043066	negative regulation of apoptotic process
GO:0050819	negative regulation of coagulation

	Cellular Component
GO:0005576	extracellular region
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005925	focal adhesion
GO:0009897	external side of plasma membrane
GO:0012506	vesicle membrane
GO:0016020	membrane
GO:0042383	sarcolemma
GO:0062023	collagen-containing extracellular matrix
GO:0070062	extracellular exosome
GO:0072563	endothelial microparticle

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