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Structure of PDB 1and Chain A Binding Site BS01

Receptor Information >1and Chain A (length=223) Species: 10117 (Rattus rattus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] IVGGYTCQENSVPYQVSLNSGYHFCGGSLINDQWVVSAAHCYKSRIQVRL GEHNINVLEGNEQFVNAAKIIKHPNFDHKTLNNDIMLIKLSSPVKLNARV ATVALPSSCAPAGTQCLISGWGNTLSSGVNEPDLLQCLDAPLLPQADCEA SYPGKITDNMVCVGFLEGGKDSCQGDSGGPVVCNGELQGIVSWGYGCALP DNPGVYTKVCNYVDWIQDTIAAN

Ligand information Ligand ID CU InChI InChI=1S/Cu/q+2 InChIKey JPVYNHNXODAKFH-UHFFFAOYSA-N SMILES Software SMILES ACDLabs 10.04 OpenEye OEToolkits 1.5.0 [Cu+2] CACTVS 3.341 [Cu++] Formula Cu Name COPPER (II) ION ChEMBL DrugBank DB14552 ZINC PDB chain 1and Chain A Residue 246 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 1and Structure of an engineered, metal-actuated switch in trypsin. Resolution 2.3 Å Binding residue (original residue number in PDB) H57 H96 Binding residue (residue number reindexed from 1) H40 H78 Annotation score 3

Enzymatic activity Catalytic site (original residue number in PDB) H57 D102 Q192 G193 D194 S195 G196 Catalytic site (residue number reindexed from 1) H40 D84 Q174 G175 D176 S177 G178 Enzyme Commision number 3.4.21.4: trypsin.

Gene Ontology Molecular Function GO:0004252 serine-type endopeptidase activity GO:0005509 calcium ion binding GO:0005515 protein binding GO:0008236 serine-type peptidase activity GO:0046872 metal ion binding

	Biological Process
GO:0006508	proteolysis
GO:0007584	response to nutrient
GO:0007586	digestion
GO:0030574	collagen catabolic process

	Cellular Component
GO:0005576	extracellular region
GO:0005615	extracellular space

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