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BioLiP

Structure of PDB 3jce Chain x

Receptor sequence
>3jcex (length=586) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
RNFSIIAHIDHGKSTLSDRIIQICAQVLDSMDLERERGITIKAQSVTLDY
KASDGETYQLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAGQGVEAQTL
ANCYTAMEMDLEVVPVLNKIDLPAADPERVAEEIEDIVGIDATDAVRCSA
KTGVGVQDVLERLVRDIPPPEGDPEGPLQALIIDSWFDNYLGVVSLIRIK
NGTLRKGDKVKVMSTGQTYNADRLGIFTPKQVDRTELKCGEVGWLVCAIK
DIHGAPVGDTLTLARNPAEKALPGFKKVKPQVYAGLFPVSSDDYEAFRDA
LGKLSLNDASLFYEPESSSALGFGFRCGFLGLLHMEIIQERLEREYDLDL
ITTAPTVVYEVETTSREVIYVDSPSKLPAVNNIYELREPIAECHMLLPQA
YLGNVITLCVEKRGVQTNMVYHGNQVALTYEIPMAEVVLDFFDRLKSTSR
GYASLDYNFKRFQASDMVRVDVLINGERVDALALITHRDNSQNRGRELVE
KMKDLIPRQQFDIAIQAAIGTHIIARSTVKQLRKNVLAKCYGGDISRKKK
LLQKQKEGKKRMKQIGNVELPQEAFLAILHVGKDNK
3D structure
PDB3jce EF4 disengages the peptidyl-tRNA CCA end and facilitates back-translocation on the 70S ribosome
Chainx
Resolution3.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K17 S18 T53 H81
Catalytic site (residue number reindexed from 1) K13 S14 T40 H68
Enzyme Commision number 3.6.5.n1: elongation factor 4.
Interaction with ligand
Gene Ontology
Molecular Function
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0042802 identical protein binding
GO:0043022 ribosome binding
GO:0043023 ribosomal large subunit binding
GO:0043024 ribosomal small subunit binding
GO:0097216 guanosine tetraphosphate binding
Biological Process
GO:0006412 translation
GO:0006414 translational elongation
GO:0009268 response to pH
GO:0009409 response to cold
GO:0009651 response to salt stress
GO:0042274 ribosomal small subunit biogenesis
GO:0045727 positive regulation of translation
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane

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Cellular Component
External links
PDB RCSB:3jce, PDBe:3jce, PDBj:3jce
PDBsum3jce
PubMed26809121
UniProtP60785|LEPA_ECOLI Elongation factor 4 (Gene Name=lepA)

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