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BioLiP

Structure of PDB 1z2p Chain X

Receptor sequence
>1z2pX (length=311) Species: 294381 (Entamoeba histolytica HM-1:IMSS) [Search protein sequence]
QTVSLFIWLPESKQKTLFISTKNHTQFELNNIIFDVTLSTELPDKEPNAI
ITKRTHPVGKMADEMRKYEKDHPKVLFLESSAIHDMMSSREEINALLIKN
NIPIPNSFSVKSKEEVIQLLQSKQLILPFIVKPENAQGTFNAHQMKIVLE
QEGIDDIHFPCLCQHYINHNNKIVKVFCIGNTLKWQTRTSLPNVHRCGIK
SVDFNNQHLEDILSWPEGVIDKQDIIENSANRFGSKILEDPILLNLTSEA
EMRDLAYKVRCALGVQLCGIDFIKENEQGNPLVVDVNVFPSYGGKVDFDW
FVEKVALCYTE
3D structure
PDB1z2p Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase.
ChainX
Resolution1.22 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.134: inositol-tetrakisphosphate 1-kinase.
2.7.1.159: inositol-1,3,4-trisphosphate 5/6-kinase.
Interaction with ligand
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016853 isomerase activity
GO:0046872 metal ion binding
GO:0047325 inositol-3,4,5,6-tetrakisphosphate 1-kinase activity
GO:0052725 inositol-1,3,4-trisphosphate 6-kinase activity
GO:0052726 inositol-1,3,4-trisphosphate 5-kinase activity
Biological Process
GO:0016310 phosphorylation
GO:0032957 inositol trisphosphate metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1z2p, PDBe:1z2p, PDBj:1z2p
PDBsum1z2p
PubMed15837423
UniProtQ9XYQ1|ITPK1_ENTH1 Inositol-tetrakisphosphate 1-kinase (Gene Name=ITPK1)

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