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BioLiP

Structure of PDB 8uhd Chain V

Receptor sequence
>8uhdV (length=550) Species: 9606 (Homo sapiens) [Search protein sequence]
LQDLGVANGEDLKETLTNCTEPLKAIEQFQTENGVLLPSLQSALPFLDLH
GTPRLEFHQSVFDELRDKLLERVSAIASEGKAEERYKKLEDLLEKSFSLV
KMPSLQPVVMCVMKHLPKVPEKKLKLVMADKELYRACAVEVKRQIWQDNQ
ALFGDEVSPLLKQYILEKESALFSTELSVLHNFFSPSPKTRRQGEVVQRL
TRMVGKNVKLYDMVLQFLRTLFLRTRNVHYCTLRAELLMSLHDLDVGEIC
TVDPCHKFTWCLDACIRERFVDSKRARELQGFLDGVKKGQEQVLGDLSMI
LCDPFAINTLALSTVRHLQELVGQETLPRDSPDLLLLLRLLALGQGAWDM
IDSQVFKEPKMEVELITRFLPMLMSFLVDDYTFNVDQKLPAEEKAPVSYP
NTLPESFTKFLQEQRMACEVGLYYVLHITKQRNKNALLRLLPGLVETFGD
LAFGDIFLHLLTGNLALLADEFALEDFCSSLFDGFFLTASPRKENVHRHA
LRLLIHLHPRVAPSKLEALQKALEPTGQSGEAVKELYSQLGEKLEQLDHR
3D structure
PDB8uhd Distinct negative elongation factor conformations regulate RNA polymerase II promoter-proximal pausing.
ChainV
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide V E329 T371 R372 M376 M378 S379 D383 E325 T367 R368 M372 M374 S375 D379
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0008283 cell population proliferation
GO:0034244 negative regulation of transcription elongation by RNA polymerase II
GO:0045892 negative regulation of DNA-templated transcription
GO:0048863 stem cell differentiation
GO:2000737 negative regulation of stem cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0032021 NELF complex

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Cellular Component
External links
PDB RCSB:8uhd, PDBe:8uhd, PDBj:8uhd
PDBsum8uhd
PubMed38401543
UniProtQ8WX92|NELFB_HUMAN Negative elongation factor B (Gene Name=NELFB)

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