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BioLiP

Structure of PDB 3ox7 Chain U

Receptor sequence
>3ox7U (length=245) Species: 9606 (Homo sapiens) [Search protein sequence]
IIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFID
YPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSALAHHNDIALLK
IRSKEGRCAQPSRTIQTIALPSMYNDPQFGTSCEITGFGKEQSTDYLYPE
QLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPL
VCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKE
3D structure
PDB3ox7 The binding mechanism of a peptidic cyclic serine protease inhibitor
ChainU
Resolution1.58 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.73: u-plasminogen activator.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide U H57 C58 D60A Y60B H99 D189 S190 C191 Q192 G193 S195 S214 W215 G219 E244 H46 C47 D50 Y51 H92 D190 S191 C192 Q193 G194 S196 S215 W216 G219 E245
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3ox7, PDBe:3ox7, PDBj:3ox7
PDBsum3ox7
PubMed21802428
UniProtP00749|UROK_HUMAN Urokinase-type plasminogen activator (Gene Name=PLAU)

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