Structure of PDB 8xt2 Chain Se

Receptor sequence
>8xt2Se (length=350) Species: 9606 (Homo sapiens) [Search protein sequence]
SRTNENDPAKHGDQHEGQHYNISPQDLETVFPHGLPPRFVMQVKTFSEAC
LMVRKPALELLHYLKNTSFAYPAIRYLLYGEKGTGKTLSLCHVIHFCAKQ
DWLILHIPDAHLWVKNCRDLLQSSYNKQRFDQPLEASTWLKNFKTTNERF
LNQIKVQEKYVWNKRESTEKGSPLGEVVEQGITRVRNATDAVGIVLKELK
RQSSLGMFHLLVAVDGINALWGRTTLKREDKSPIAPEELALVHNLRKMMK
NDWHGGAIVSALSQTGSLFKPRKAYLPQELLGKEGFDALDPFIPILVSNY
NPKEFESCIQYYLENNWLQHEKAPTEEGKKELLFLSNANPSLLERHCAYL
3D structure
PDB8xt2 Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.
ChainSe
Resolution3.3 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna Se K130 L160 K163 N164 R166 T313 F317 K318 R320 S389 L390 R393 K82 L112 K115 N116 R118 T265 F269 K270 R272 S341 L342 R345
BS02 GDP Se R86 F87 Q90 M100 G131 T132 G133 K134 T135 L136 Y348 E392 R38 F39 Q42 M52 G83 T84 G85 K86 T87 L88 Y300 E344
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0005525 GTP binding
Biological Process
GO:0006915 apoptotic process
GO:0032543 mitochondrial translation
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005763 mitochondrial small ribosomal subunit
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8xt2, PDBe:8xt2, PDBj:8xt2
PDBsum8xt2
PubMed38942792
UniProtP51398|RT29_HUMAN Small ribosomal subunit protein mS29 (Gene Name=DAP3)

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