BioLiP

Structure of PDB 8xt2 Chain Se

Receptor sequence

>8xt2Se (length=350) Species: 9606 (Homo sapiens) [Search protein sequence]

SRTNENDPAKHGDQHEGQHYNISPQDLETVFPHGLPPRFVMQVKTFSEAC
LMVRKPALELLHYLKNTSFAYPAIRYLLYGEKGTGKTLSLCHVIHFCAKQ
DWLILHIPDAHLWVKNCRDLLQSSYNKQRFDQPLEASTWLKNFKTTNERF
LNQIKVQEKYVWNKRESTEKGSPLGEVVEQGITRVRNATDAVGIVLKELK
RQSSLGMFHLLVAVDGINALWGRTTLKREDKSPIAPEELALVHNLRKMMK
NDWHGGAIVSALSQTGSLFKPRKAYLPQELLGKEGFDALDPFIPILVSNY
NPKEFESCIQYYLENNWLQHEKAPTEEGKKELLFLSNANPSLLERHCAYL

3D structure

PDB

8xt2 Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.

Chain

Resolution

3.3 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	Se	K130 L160 K163 N164 R166 T313 F317 K318 R320 S389 L390 R393	K82 L112 K115 N116 R118 T265 F269 K270 R272 S341 L342 R345
BS02	GDP	Se	R86 F87 Q90 M100 G131 T132 G133 K134 T135 L136 Y348 E392	R38 F39 Q42 M52 G83 T84 G85 K86 T87 L88 Y300 E344

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0005525	GTP binding

	Biological Process
GO:0006915	apoptotic process
GO:0032543	mitochondrial translation
GO:0097190	apoptotic signaling pathway

	Cellular Component
GO:0005654	nucleoplasm
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005763	mitochondrial small ribosomal subunit
GO:0005840	ribosome
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

PDB	RCSB:8xt2, PDBe:8xt2, PDBj:8xt2
PDBsum	8xt2
PubMed	38942792
UniProt	P51398\|RT29_HUMAN Small ribosomal subunit protein mS29 (Gene Name=DAP3)