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BioLiP

Structure of PDB 5lks Chain Sb

Receptor sequence
>5lksSb (length=83) Species: 9606 (Homo sapiens) [Search protein sequence]
PLAKDLLHPSPEEEKRKHKKKRLVQSPNSYFMDVKCPGCYKITTVFSHAQ
TVVLCVGCSTVLCQPTGGKARLTEGCSFRRKQH
3D structure
PDB5lks Structure-function insights reveal the human ribosome as a cancer target for antibiotics.
ChainSb
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna Sb R17 H19 K20 K21 K22 Q26 P28 S30 F47 H49 Q51 T67 G68 G69 K70 R72 R16 H18 K19 K20 K21 Q25 P27 S29 F46 H48 Q50 T66 G67 G68 K69 R71
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0002181 cytoplasmic translation
GO:0006364 rRNA processing
GO:0006412 translation
GO:0042274 ribosomal small subunit biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0014069 postsynaptic density
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0032040 small-subunit processome
GO:1990904 ribonucleoprotein complex

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Cellular Component
External links
PDB RCSB:5lks, PDBe:5lks, PDBj:5lks
PDBsum5lks
PubMed27665925
UniProtP42677|RS27_HUMAN Small ribosomal subunit protein eS27 (Gene Name=RPS27)

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