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BioLiP

Structure of PDB 7xw9 Chain R

Receptor sequence
>7xw9R (length=288) Species: 9606 (Homo sapiens) [Search protein sequence]
QLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNC
YLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINAS
SCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFF
LLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYG
FIARILFLTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQE
NWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCN
3D structure
PDB7xw9 Cryo-EM structure of the TRH-bound human TRHR-Gq complex
ChainR
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide R T102 Y106 L164 Y181 R185 Y282 N289 R306 T90 Y94 L152 Y169 R173 Y234 N241 R258
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004997 thyrotropin-releasing hormone receptor activity
GO:0005515 protein binding
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:7xw9, PDBe:7xw9, PDBj:7xw9
PDBsum7xw9
PubMed36280665
UniProtP34981|TRFR_HUMAN Thyrotropin-releasing hormone receptor (Gene Name=TRHR)

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