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BioLiP

Structure of PDB 7xow Chain R

Receptor sequence
>7xowR (length=276) Species: 9606 (Homo sapiens) [Search protein sequence]
ELAIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLL
LAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALER
YSAICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPVYTVVQPVGPRV
LQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGKLLA
KKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHL
LSYASACVNPLVYCFMHRRFRQACLE
3D structure
PDB7xow Structural insights into human brain-gut peptide cholecystokinin receptors.
ChainR
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide R P114 G118 T119 M134 Y189 Q204 C205 H207 N353 R356 A363 H364 S368 I372 H376 P62 G66 T67 M82 Y137 Q152 C153 H155 N226 R229 A236 H237 S241 I245 H249
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004951 cholecystokinin receptor activity
GO:0005515 protein binding
GO:0015054 gastrin receptor activity
GO:0017046 peptide hormone binding
GO:0031741 type B gastrin/cholecystokinin receptor binding
GO:0046935 1-phosphatidylinositol-3-kinase regulator activity
Biological Process
GO:0001696 gastric acid secretion
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0008284 positive regulation of cell population proliferation
GO:0038188 cholecystokinin signaling pathway
GO:0045851 pH reduction
GO:0048565 digestive tract development
GO:0048732 gland development
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle

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Cellular Component
External links
PDB RCSB:7xow, PDBe:7xow, PDBj:7xow
PDBsum7xow
PubMed35672283
UniProtP32239|GASR_HUMAN Gastrin/cholecystokinin type B receptor (Gene Name=CCKBR)

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