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BioLiP

Structure of PDB 7t10 Chain R

Receptor sequence
>7t10R (length=287) Species: 9606 (Homo sapiens) [Search protein sequence]
LTSNAVLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIAD
ELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSID
RYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQGR
SSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSVRL
LSGSREKDRNLRKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPAL
KGMFDFVVVLTYANSCANPILYAFLSDNFKKSFQNVL
3D structure
PDB7t10 Plasticity in ligand recognition at somatostatin receptors.
ChainR
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide R D122 R184 Y205 F272 N276 P286 K291 F294 Y302 D83 R145 Y165 F232 N236 P246 K251 F254 Y262
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004994 somatostatin receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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External links
PDB RCSB:7t10, PDBe:7t10, PDBj:7t10
PDBsum7t10
PubMed35210615
UniProtP30874|SSR2_HUMAN Somatostatin receptor type 2 (Gene Name=SSTR2);
P41145|OPRK_HUMAN Kappa-type opioid receptor (Gene Name=OPRK1)

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