BioLiP

Structure of PDB 6oij Chain R

Receptor sequence

>6oijR (length=293) Species: 9606 (Homo sapiens) [Search protein sequence]

PWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACAD
LIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASQASVMNLLLISF
DRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGER
TVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARE
LAALQGEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELG
YWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIP

3D structure

PDB

6oij Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes.

Chain

Resolution

3.3 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	IXO	R	D105 Y106 S109 Q110 A196 F197 W378 Y381 Y404 C407 Y408	D84 Y85 S88 Q89 A175 F176 W225 Y228 Y251 C254 Y255
BS02	Y01	R	C205 I383	C184 I230
BS03	Y01	R	C69 A143 I146 W150	C48 A122 I125 W129

Gene Ontology

	Molecular Function
GO:0004930	G protein-coupled receptor activity
GO:0016907	G protein-coupled acetylcholine receptor activity

	Biological Process
GO:0007186	G protein-coupled receptor signaling pathway
GO:0040012	regulation of locomotion
GO:0046541	saliva secretion
GO:0050890	cognition

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane

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Cellular Component

PDB	RCSB:6oij, PDBe:6oij, PDBj:6oij
PDBsum	6oij
PubMed	31073061
UniProt	P11229\|ACM1_HUMAN Muscarinic acetylcholine receptor M1 (Gene Name=CHRM1)