BioLiP

Structure of PDB 7r4f Chain N

Receptor sequence

>7r4fN (length=347) Species: 9913 (Bos taurus) [Search protein sequence]

MNPIIFIIILLTIMLGTIIVMISSHWLLVWIGFEMNMLAIIPIMMKNHNP
RATEASTKYFLTQSTASMLLMMAVIINLMFSGQWTVMKLFNPMASMLMTM
ALAMKLGMAPFHFWVPEVTQGIPLSSGLILLTWQKLAPMSVLYQIFPSIN
LNLILTLSVLSILIGGWGGLNQTQLRKIMAYSSIAHMGWMTAVLPYNPTM
TLLNLIIYIIMTSTMFTMFMANSTTTTLSLSHTWNKTPIMTVLILATLLS
MGGLPPLSGFMPKWMIIQEMTKNNSIILPTFMAITALLNLYFYMRLTYST
TLTMFPSTNNMKMKWQFPLMKKMTFLPTMVVLSTMMLPLTPMLSVLE

3D structure

PDB

7r4f Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides.

Chain

Resolution

2.4 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

7.1.1.2: NADH:ubiquinone reductase (H(+)-translocating).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	N	L155 P195 Y196 N273 N274	L155 P195 Y196 N273 N274
BS02	I49	N	N197 E347	N197 E347

Gene Ontology

	Molecular Function
GO:0008137	NADH dehydrogenase (ubiquinone) activity

	Biological Process
GO:0006120	mitochondrial electron transport, NADH to ubiquinone
GO:0032981	mitochondrial respiratory chain complex I assembly
GO:1902600	proton transmembrane transport

	Cellular Component
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0045271	respiratory chain complex I

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Molecular Function

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Cellular Component

PDB	RCSB:7r4f, PDBe:7r4f, PDBj:7r4f
PDBsum	7r4f
PubMed	36701435
UniProt	P03892\|NU2M_BOVIN NADH-ubiquinone oxidoreductase chain 2 (Gene Name=MT-ND2)