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BioLiP

Structure of PDB 8xt2 Chain LU

Receptor sequence
>8xt2LU (length=160) Species: 9606 (Homo sapiens) [Search protein sequence]
SYLPGYVPKTSLSSPPWPEVVLPDPVEETRHHAEVVKKVNEMIVTGQYGR
LFAVVHFASRQWKVTSEDLILIGNELDLACGERIRLEKVLLVGADNFTLL
GKPLLGKDLVRVEATVIEKTESWPRIIMRFRKRKNFKKKRIVTTPQTVLR
INSIEIAPCL
3D structure
PDB8xt2 Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.
ChainLU
Resolution3.3 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna LU W61 P62 A102 S103 R104 N118 R169 I171 R173 F174 R175 K176 R177 K178 K182 K183 R184 T188 W17 P18 A58 S59 R60 N74 R125 I127 R129 F130 R131 K132 R133 K134 K138 K139 R140 T144
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0032543 mitochondrial translation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

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External links
PDB RCSB:8xt2, PDBe:8xt2, PDBj:8xt2
PDBsum8xt2
PubMed38942792
UniProtQ7Z2W9|RM21_HUMAN Large ribosomal subunit protein bL21m (Gene Name=MRPL21)

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