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BioLiP

Structure of PDB 2a2q Chain L

Receptor sequence
>2a2qL (length=142) Species: 9606 (Homo sapiens) [Search protein sequence]
ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQC
ASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQ
YCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILE
3D structure
PDB2a2q High resolution structures of p-aminobenzamidine- and benzamidine-VIIa/soluble tissue factor: unpredicted conformation of the 192-193 peptide bond and mapping of Ca2+, Mg2+, Na+, and Zn2+ sites in factor VIIa.
ChainL
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.21: coagulation factor VIIa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLC L Q49 S52 P54 Q49 S52 P54
BS02 FUC L S60 L73 S60 L73
BS03 MG L E25 E29 E25 E29
BS04 CA L E26 E29 E26 E29
BS05 CA L E26 E29 E26 E29
BS06 MG L E16 E26 E16 E26
BS07 CA L A1 E16 E20 A1 E16 E20
BS08 CA L E6 E20 E6 E20
BS09 MG L E14 E19 E14 E19
BS10 CA L D46 G47 Q49 D63 Q64 D46 G47 Q49 D63 Q64
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Cellular Component
External links
PDB RCSB:2a2q, PDBe:2a2q, PDBj:2a2q
PDBsum2a2q
PubMed16757484
UniProtP08709|FA7_HUMAN Coagulation factor VII (Gene Name=F7)

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