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BioLiP

Structure of PDB 1wv7 Chain L

Receptor sequence
>1wv7L (length=142) Species: 9606 (Homo sapiens) [Search protein sequence]
ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQC
ASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQ
YCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILE
3D structure
PDB1wv7 Structure-based design of P3 moieties in the peptide mimetic factor VIIa inhibitor
ChainL
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.21: coagulation factor VIIa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BGC L Q49 S52 Y68 Q49 S52 Y68
BS02 FUC L G58 S60 F71 C72 G58 S60 F71 C72
BS03 CA L D46 G47 Q49 D63 Q64 D46 G47 Q49 D63 Q64
BS04 CA L E7 E26 E29 E7 E26 E29
BS05 CA L E7 E16 E26 E29 E7 E16 E26 E29
BS06 CA L A1 N2 E6 E7 E16 E26 A1 N2 E6 E7 E16 E26
BS07 CA L A1 E6 E16 E20 A1 E6 E16 E20
BS08 CA L E14 E19 E14 E19
BS09 CA L E25 E29 E25 E29
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Cellular Component
External links
PDB RCSB:1wv7, PDBe:1wv7, PDBj:1wv7
PDBsum1wv7
PubMed15629154
UniProtP08709|FA7_HUMAN Coagulation factor VII (Gene Name=F7)

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