Structure of PDB 7dy2 Chain K

Receptor sequence

>7dy2K (length=465) Species: 1140 (Synechococcus elongatus PCC 7942 = FACHB-805) [Search protein sequence]

HQAIAKMRTMIEGFDDISHGGLPIGRSTLVSGTSGTGKTLFSIQFLYNGI
IEFDEPGVFVTFEETPQDIIKNARSFGWLAKLVDEGKLFILDASPDDLSA
LIERINYAIQKYRARRVSIDSVTSVFQQYDASSVVRRELFRLVARLKQIG
ATTVMTTERIEEYGPIARYGVEEFVSDNVVILRNVLEGERRRRTLEILKL
RGTSHMKGEYPFTITDHGINIFPQRSSNVRVSSGVVRLDEMCGGGFFKDS
IILATGATGTGKTLLVSRFVENACANKERAILFAYEESRAQLLRNAYSWG
MDFEEMERQNLLKIVCAYPESAGLEDHLQIIKSEINDFKPARIAIDSLSA
LARGVSNNAFRQFVIGVTGYAKQEEITGLFTNTSDQFMGAHSITDSHIST
ITDTIILLQYVEIRGEMSRAINVFKMRGSWHDKAIREFMISDKGPDIKDS
FRNFERIISGSPTRI

3D structure

PDB

7dy2 Elucidation of master allostery essential for circadian clock oscillation in cyanobacteria.

Chain

Resolution

3.04 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.11.1: non-specific serine/threonine protein kinase.
3.6.4.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ADP	K	G49 G51 K52 T53 L54 S89 F90 R218	G35 G37 K38 T39 L40 S75 F76 R193
BS02	ATP	K	T290 G291 T292 G293 K294 T295 W331 R451	T258 G259 T260 G261 K262 T263 W299 R419
BS03	ATP	K	K457 M458 R459 S461 W462 H463 K465	K425 M426 R427 S429 W430 H431 K433
BS04	ATP	K	K224 L225 G227 T228 S229 H230	K199 L200 G202 T203 S204 H205

Gene Ontology

	Molecular Function
GO:0000287	magnesium ion binding
GO:0003677	DNA binding
GO:0004674	protein serine/threonine kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0016887	ATP hydrolysis activity
GO:0042802	identical protein binding
GO:0044024	histone H2AS1 kinase activity
GO:0046872	metal ion binding
GO:0106310	protein serine kinase activity

	Biological Process
GO:0006338	chromatin remodeling
GO:0006355	regulation of DNA-templated transcription
GO:0007623	circadian rhythm
GO:0009649	entrainment of circadian clock
GO:0016310	phosphorylation
GO:0042752	regulation of circadian rhythm
GO:0042754	negative regulation of circadian rhythm
GO:0048511	rhythmic process
GO:0070297	regulation of phosphorelay signal transduction system

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:7dy2, PDBe:7dy2, PDBj:7dy2
PDBsum	7dy2
PubMed	35427168
UniProt	Q79PF4\|KAIC_SYNE7 Circadian clock oscillator protein KaiC (Gene Name=kaiC)

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