Structure of PDB 1h0h Chain K

Receptor sequence

>1h0hK (length=977) Species: 879 (Megalodesulfovibrio gigas)

ATMALKTVDAKQTTSVCCYCSVGCGLIVHTDKKTNRAINVEGDPDHPINE
GSLCAKGASTWQLAENERRPANPLYRAPGSDQWEEKSWDWMLDTIAERVA
KTREATFVTKNAKGQVVNRCDGIASVGSAAMDNEECWIYQAWLRSLGLFY
IEHQARICHSATVAALAESYGRGAMTNHWIDLKNSDVILMMGSNPAENHP
ISFKWVMRAKDKGATLIHVDPRYTRTSTKCDLYAPLRSGSDIAFLNGMTK
YILEKELYFKDYVVNYTNASFIVGEGFAFEEGLFAGYNKETRKYDKSKWG
FERDENGNPKRDETLKHPRCVFQIMKKHYERYDLDKISAICGTPKELILK
VYDAYCATGKPDKAGTIMYAMGWTQHTVGVQNIRAMSINQLLLGNIGVAG
GGVNALRGEANVQGSTDHGLLMHIYPGYLGTARASIPTYEEYTKKFTPVS
KDPQSANWWSNFPKYSASYIKSMWPDADLNEAYGYLPKGEDGKDYSWLTL
FDDMFQGKIKGFFAWGQNPACSGANSNKTREALTKLDWMVNVNIFDNETG
SFWRGPDMDPKKIKTEVFFLPCAVAIEKEGSISNSGRWMQWRYVGPEPRK
NAIPDGDLIVELAKRVQKLLAKTPGKLAAPVTKLKTDYWVNDHGHFDPHK
IAKLINGFALKDFKVGDVEYKAGQQIATFGHLQADGSTTSGCWIYTGSYT
EKGNMAARRDKTQTDMQAKIGLYPGWTWAWPVNRRIIYNRASVDLNGKPY
APEKAVVEWNAAEKKWVGDVPDGPWPPQADKEKGKRAFIMKPEGYAYLYG
PGREDGPLPEYYEPMECPVIEHPFSKTLHNPTALHFATEEKAVCDPRYPF
ICSTYRVTEHWQTGLMTRNTPWLLEAEPQMFCEMSEELATLRGIKNGDKV
ILESVRGKLWAKAIITKRIKPFAIQGQQVHMVGIPWHYGWSFPKNGGDAA
NILTPSVGNPNTGIPETKAFMVNVTKA

3D structure

• PDB: 1h0h Gene Sequence and the 1.8 A Crystal Structure of the Tungsten-Containing Formate Dehydrogenase from Desulfovibrio Gigas
• Chain: K
• Resolution: 1.8 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): C158 M371 R407 G408 E409
• Catalytic site (residue number reindexed from 1): C158 M371 R407 G408 E409
• Enzyme Commision number: 1.17.1.9: formate dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	2MD	K	A130 Q154 I157 U158 M371 G516 Q517 N518 S522 V542 N543 I544 C572 D605 T854 R856 Q862 T863 M866 W936 N951 T967	A130 Q154 I157 U158 M371 G516 Q517 N518 S522 V542 N543 I544 C572 D605 T854 R856 Q862 T863 M866 W936 N951 T967
BS02	MGD	K	K56 U158 G192 S193 N194 N198 D220 P221 R222 S238 G239 D241 A370 M371 G408 Y855 R856 T858 H860 W861 Q862 K968	K56 U158 G192 S193 N194 N198 D220 P221 R222 S238 G239 D241 A370 M371 G408 Y855 R856 T858 H860 W861 Q862 K968
BS03	SF4	K	C17 Y19 C20 V22 C24 L53 C54 K56 G57 P200 I201	C17 Y19 C20 V22 C24 L53 C54 K56 G57 P200 I201
BS04	CA	K	T358 K360 K363 L393 G394 N395	T358 K360 K363 L393 G394 N395

Gene Ontology

Molecular Function

• GO:0008863 formate dehydrogenase (NAD+) activity
• GO:0009055 electron transfer activity
• GO:0016491 oxidoreductase activity
• GO:0030151 molybdenum ion binding
• GO:0043546 molybdopterin cofactor binding
• GO:0046872 metal ion binding
• GO:0047111 formate dehydrogenase (cytochrome-c-553) activity
• GO:0051539 4 iron, 4 sulfur cluster binding

Biological Process

• GO:0009061 anaerobic respiration
• GO:0045333 cellular respiration

Cellular Component

• GO:0042597 periplasmic space

External links

• PDB: RCSB:1h0h, PDBe:1h0h, PDBj:1h0h
• PDBsum: 1h0h
• PubMed: 12220497
• UniProt: Q934F5|FDHA_MEGGA Formate dehydrogenase subunit alpha (Gene Name=fdhA)