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Structure of PDB 8bwf Chain I

Receptor sequence

>8bwfI (length=77) Species: 9606 (Homo sapiens)

PPSRVIHIRKLPIDVTEGEVISLGLPFGKVTNLLMLKGKNQAFIEMNTEE
AANTMVNYYTSVTPVLRGQPIYIQFSN

3D structure

• PDB: 8bwf Rationally designed stapled peptides allosterically inhibit PTBP1-RNA-binding.
• Chain: I
• Resolution: 2.9 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	I	E72 I76 V85 N87 L88	E17 I21 V30 N32 L33

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003723 RNA binding

External links

• PDB: RCSB:8bwf, PDBe:8bwf, PDBj:8bwf
• PDBsum: 8bwf
• PubMed: 37564416
• UniProt: P26599|PTBP1_HUMAN Polypyrimidine tract-binding protein 1 (Gene Name=PTBP1)

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