BioLiP

Structure of PDB 4e2s Chain H

Receptor sequence

>4e2sH (length=258) Species: 3702 (Arabidopsis thaliana) [Search protein sequence]

PIYWKATNPTLSPSHLQDLPGFTRSVYKRDHALITPESHVYSPLPDWTNT
LGAYLITPATGSHFVMYLAKMKEMSSSGLPPQDIERLIFVVEGAVTLTNS
SSKKLTVDSYAYLPPNFHHSLDCVESATLVVFERRYEYLGSHTTELIVGS
TDKQPLLETPGEVFELRKLLPMSVAYDFNIHTMDFQPGEFLNVKEVHYNQ
HGLLLLEGQGIYRLGDNWYPVQAGDVIWMAPFVPQWYAALGKTRSRYLLY
KDVNRNPL

3D structure

PDB

4e2s Structural and functional insights into (S)-ureidoglycine aminohydrolase, key enzyme of purine catabolism in Arabidopsis thaliana

Chain

Resolution

2.59 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.5.3.26: (S)-ureidoglycine aminohydrolase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MN	H	E235 H237 H241 Q275	E195 H197 H201 Q235
BS02	UGY	H	M223 E235 H241 Y252 Q275 Y287	M183 E195 H201 Y212 Q235 Y247

Gene Ontology

	Molecular Function
GO:0003700	DNA-binding transcription factor activity
GO:0016787	hydrolase activity
GO:0046872	metal ion binding
GO:0071522	ureidoglycine aminohydrolase activity

	Biological Process
GO:0000256	allantoin catabolic process
GO:0006144	purine nucleobase metabolic process
GO:0006145	purine nucleobase catabolic process
GO:0006355	regulation of DNA-templated transcription
GO:0010136	ureide catabolic process

	Cellular Component
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol

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Molecular Function

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Biological Process

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Cellular Component

PDB	RCSB:4e2s, PDBe:4e2s, PDBj:4e2s
PDBsum	4e2s
PubMed	22493446
UniProt	Q8GXV5\|UGHY_ARATH (S)-ureidoglycine aminohydrolase (Gene Name=UGLYAH)