Structure of PDB 3ls4 Chain H

Receptor sequence

>3ls4H (length=219) Species: 10090 (Mus musculus) [Search protein sequence]

EVKLVESGGGLVKPGGSLKLSCAASGFTFNNYVMVWLRQTPEKRLEWVAS
ISRGGSTYYPDSVKGRFTISRDNARNILYLQMSSLRSEDTAMYYCVRGTT
IVAGDVWGAGTTVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYF
PEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCN
VAHPASSTKVDKKIVPRDC

3D structure

PDB

3ls4 A structural insight into the molecular recognition of a (-)-Delta9-tetrahydrocannabinol and the development of a sensitive, one-step, homogeneous immunocomplex-based assay for its detection

Chain

Resolution

2.0 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	TCI	H	V33 V35 S50 Y58 G98 T99 V102 A103 G104	V33 V35 S50 Y58 G98 T99 V102 A103 G104	PDBbind-CN: -logKd/Ki=6.30,IC50=500nM

External links

PDB	RCSB:3ls4, PDBe:3ls4, PDBj:3ls4
PDBsum	3ls4
PubMed	20630472

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