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BioLiP

Structure of PDB 2c4f Chain H

Receptor sequence
>2c4fH (length=254) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWR
NLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPV
VLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNV
PRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHY
RGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLR
APFP
3D structure
PDB2c4f The Discovery of Fluoropyridine-Based Inhibitors of the Factor Viia/Tf Complex--Part 2
ChainH
Resolution1.72 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.21: coagulation factor VIIa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA H E70 D72 E75 E80 E58 D60 E63 E68
BS02 GIL H H57 T99 D189 S190 K192 G193 S195 V213 S214 W215 G216 H41 T87 D186 S187 K189 G190 S192 V210 S211 W212 G213 PDBbind-CN: -logKd/Ki=7.70,IC50=20nM
BindingDB: IC50=20nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2c4f, PDBe:2c4f, PDBj:2c4f
PDBsum2c4f
PubMed16289811
UniProtP08709|FA7_HUMAN Coagulation factor VII (Gene Name=F7)

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